L 012 sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 5085
Chemiluminescent ROS and RNS indicator
Key Product Details
Description
Chemiluminescent ROS and RNS indicator
Product Description
L 012 sodium salt is a luminal-based chemiluminescent probe. Detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). Active in vitro and in vivo.Spectra Viewer
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Product Specifications
Molecular Weight
310.67
Formula
C13H8CIN4NaO2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
8-Amino-5-chloro-2,3-dihydro-7-phenyl-pyrido[3,4-d]pyridazine sodium salt
CAS Number
143556-24-5
PubChem ID
78243715
InChI Key
IGEUYSJHQQCEFP-UHFFFAOYSA-M
SMILES
NC1=C3C(C(O[Na])=NNC3=O)=C(Cl)N=C1C2=CC=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.21 | 20 | |
| DMSO | 31.07 | 100 |
Preparing Stock Solutions
for L 012 sodium salt
The following data is based on the product molecular weight 310.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.22 mL | 16.09 mL | 32.19 mL |
| 5 mM | 0.64 mL | 3.22 mL | 6.44 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.22 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Zhou Noninvasive assessment of localized inflammatory responses. Free Radic.Biol.Med. 2012 PMID: 22080048
- Ichibangase Evaluation of lophine derivatives as L-012 (luminol analog)-dependent chemiluminescence enhancers for measuring horseradish peroxidase and H2 O2. Luminescence. 2013 PMID: 23630098
- Kielland In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic.Biol.Med. 2009 PMID: 19539751
Product Specific Notices for L 012 sodium salt
For research use only
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