CoraFluor™ 1, thiol reactive

Product Description

CoraFluor™ 1, thiol reactive is a terbium-based time-resolved Förster resonance energy transfer (TR-FRET) donor for TR-FRET assay development, such as target engagement and ternary complex assays. This product is designed with maleimide functionality to conjugate to cysteines, making it suitable for labeling biomolecules, including antibodies, nanobodies, proteins and peptides. It is exceptionally bright, providing unmatched assay sensitivity and stability in biological media over other commercially available TR-FRET donors. CoraFluor™ 1, thiol reactive is compatible with common acceptor dyes such as FAM, TMR and Cyanine 5, SE (Cat. No. 5436), enabling seamless assay integration in high throughput screening applications.

CoraFluor™ 1, amine reactive, CoraFluor™ 2, amine reactive, CoraFluor™ 1, Haloalkane, and CoraFluor™ 2, Haloalkane, also available.

Please refer to the protocol for further information on conjugation.

For more information, please see our CoraFluor™ TR-FRET technology flyer .

CoraFluor™ is a trademark of Bio-Techne Corp.

Licensing Information

Sold for research purposes only under agreement from Massachusetts General Hospital, US Patent No. 12,134,721. A license is required for development of new commercial assay platforms (e.g., microarrays, microfluidics), diagnostic use or other unlicensed uses. Please contact Technical Support for further details: techsupport@bio-techne.com.

Optical Data

Calculators

Background References

References are publications that support the biological activity of the product.

• Payne A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader. Cell Chem.Biol. 2022 PMID: 35649410
• Payne Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors. Cell Chem.Biol. 2022 PMID: 35298895
• Payne Bright and stable luminescent probes for target engagement profiling in live cells. Nat.Chem.Biol. 2021 PMID: 34675420