BDY FL Thalidomide

Tocris Bioscience, part of Bio-Techne | Catalog # 7633

High affinity fluorescent probe for TR-FRET cereblon binding assay
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Key Product Details

Description

High affinity fluorescent probe for TR-FRET cereblon binding assay

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Product Description

BDY FL Thalidomide is a high-affinity fluorescent probe (Kd = 3.6 nM). It can be used in time-resolved fluorescence resonance energy-transfer (TR-FRET) cereblon binding assays for PROTAC® Degrader development. This assay is highly sensitive, selective, and stable. Excitation and emission maxima (λ) are 502 and 510 nm, respectively.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Optical Data

λabs 502 nm
λem 510 nm
Closest Laser line 488 nm
Application Time-resolved fluorescence energy transfer (TR-FRET)
Alternative For FAM; Alexa Fluor® 488; DyLight™ 488; Cy2

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Product Specifications

Molecular Weight

732.59

Formula

C37H43BF2N6O7

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

3-(5,5-Difluoro-7,9-dimethyl-5H-5λ4,6λ4-dipyrrolo[1,3,2]diazaborinin-3-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)propenamide

CAS Number

2740620-18-0

PubChem ID

165714709

InChI Key

CJILTFJYYOHLGA-UHFFFAOYSA-N

SMILES

O=C(CCC1N2C(C3=C(C2=O)C(OCC(NCCCCCCCCNC(CCC4=CC=C5N4[B-](F)([N+]6=C(C=C(C6=C5)C)C)F)=O)=O)=CC=C3)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.33 10

Preparing Stock Solutions for BDY FL Thalidomide

The following data is based on the product molecular weight 732.59

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.65 mL 68.25 mL 136.50 mL
0.5 mM 2.73 mL 13.65 mL 27.30 mL
1 mM 1.37 mL 6.83 mL 13.65 mL
5 mM 0.27 mL 1.37 mL 2.73 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for BDY FL Thalidomide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BDY FL Thalidomide

For research use only

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