BDY FL Lenalidomide
Tocris Bioscience, part of Bio-Techne | Catalog # 7857
Fluorescent cereblon ligand
Discontinued Product
7857 has been discontinued.
View all Fluorescent Ligands products.
Key Product Details
Description
Fluorescent cereblon ligand
Product Description
BDY FL Lenalidomide is a fluorescent cereblon ligand. It can be used in time-resolved fluorescence resonance energy-transfer (TR-FRET) cereblon binding assays for PROTAC® Degrader development. This assay is highly sensitive, selective, and stable. Excitation and emission maxima (λ) are 506 and 508 nm, respectively.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Optical Data
| Emission Color | Green |
| λabs | 506 nm |
| λem | 508 nm |
| Closest Laser line | 488 nm |
| Cell Permeable | Yes |
| Application | TR-FRET and FP Assays |
| Alternative For | BDY FL Thalidomide |
Spectra Viewer
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Product Specifications
Molecular Weight
632.52
Formula
C33H39BF2N6O4
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
3-(5,5-Difluoro-7,9-dimethyl-5H-5λ4,6λ4-dipyrrolo[1,3,2]diazaborinin-3-yl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)hexyl)propanamide
InChI Key
RCUBMUCPIXRRKQ-UHFFFAOYSA-N
SMILES
O=C(CCC1N2C(C3=C(C2)C(NCCCCCCNC(CCC4=CC=C5N4[B-](F)([N+]6=C(C=C(C6=C5)C)C)F)=O)=CC=C3)=O)NC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.33 | 10 |
Preparing Stock Solutions
for BDY FL Lenalidomide
The following data is based on the product molecular weight 632.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.81 mL | 79.05 mL | 158.10 mL |
| 0.5 mM | 3.16 mL | 15.81 mL | 31.62 mL |
| 1 mM | 1.58 mL | 7.90 mL | 15.81 mL |
| 5 mM | 0.32 mL | 1.58 mL | 3.16 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol. 2021 PMID: 34035522
Product Specific Notices for BDY FL Lenalidomide
For research use only
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