COVID-SeroKlir, Kantaro SARS-CoV-2 IgG Ab Kit 100% Prev (CA)

Name: COVID-SeroKlir, Kantaro SARS-CoV-2 IgG Ab Kit 100% Prev (CA)
Brand: Kantaro
SKU: COV219-CA100

| Catalog # COV219-CA100

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Product Datasheet / COA / SDS

Available in the Canada only. Quantitative. 100% Prevalence

Key Product Details

Discontinued Product

COV219-CA100 has been discontinued. View all Spike RBD products.

Technical Data
Citations / Reviews

Summary for COVID-SeroKlir, Kantaro SARS-CoV-2 IgG Ab Kit 100% Prev (CA)

Sample Type & Volume Required Per Well	Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL)
Sensitivity	3.2 AU/mL
Assay Range	3.2 - 125 AU/mL (Serum, EDTA Plasma, Heparin Plasma)
Specificity	Natural and recombinant human anti-SARS-CoV-2 IgG
Cross-reactivity
Interference	No significant interference observed with available related molecules.

Product Summary

The COVID-SeroKlir, Kantaro Semi-Quantitative SARS-CoV-2 IgG Antibody Kit is a two-step Enzyme-Linked Immunosorbent Assay (ELISA) intended for qualitative and semi-quantitative detection of human IgG antibodies to the SARS-CoV-2 virus in serum and Li-Heparin plasma. An initial qualitative ELISA step is performed against recombinant Receptor Binding Domain of SARS-CoV-2, followed, for positive specimens, by a confirmatory semi-quantitative ELISA step against full-length SARS-CoV-2 Spike protein. The Kantaro Biosciences Clinical Agreement Study has demonstrated a 99% specificity and 99% sensitivity in subjects 15 days post-symptom onset.

Performance Characteristics

Analytical Measuring Range	3.2 – 125 AU/mL
Linear Range	1.89 - 125.7 AU/mL
Within-Site Imprecision	See product datasheet for details.
Lot-to-Lot Imprecision	See product datasheet for details.
Site-to-Site Reproducibility	See product datasheet for details.
Analytical Sensitivity	3.20 AU/mL (see product datasheet for additional information)
Positive Percent Agreement	99.15% in subjects 15 days post symptom onset
Negative Percent Agreement	99.6%

Background: SARS-CoV-2

The coronavirus Spike protein receptor binding domain (RBD) resides within the S1 subunit and is responsible for binding to host cell receptors and initiating viral infection. Past coronaviruses SARS and MERS along with the global pandemic caused by SARS-CoV-2 have sparked great interest and scientific discovery leading to new vaccines and drug development. At the heart of coronavirus biology lies the Spike protein and its receptor binding domain. The Spike RBD is a 26 kDa domain consisting of a twisted five-stranded antiparallel beta sheet and sits at the apex of each Spike protein monomer. The Spike RBD is flexible thanks to a hinge region that allows for conformational changes that expose (up or open conformation) or hide (down or closed conformation) its receptor contacts. For SARS-CoV-2, the Spike RBD recognizes and tightly binds to the human receptor ACE-2. In the closely related MERS coronavirus, human DPPIV/CD26 acts as the receptor.

Product Specifications for COVID-SeroKlir, Kantaro SARS-CoV-2 IgG Ab Kit 100% Prev (CA)

Species	SARS-CoV-2
Source	N/A

Preparation & Storage

Shipping Conditions	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage	Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Spike RBD

Item	Value
Long Name	Spike Receptor Binding Domain
Entrez Gene IDs	3200426 (HCoV-HKU1); 14254594 (MERS-CoV); 1489668 (SARS-CoV); 43740568 (SARS-CoV-2)
Alternate Names	Spike RBD

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