Fetal Bovine Serum – Premium, Heat Inactivated is a low-endotoxin, low-hemoglobin FBS that offers excellent value for basic cell culture as well as for specific research applications. Premium grade FBS is widely used and demonstrates excellent performance with a broad spectrum of cell types.
Key Benefits:
Most widely used FBS from R&D Systems
Excellent value and performance for general cell culture applications
High lot-to-lot consistency
Manufactured from USA-origin or USDA-approved
Excellent cell growth characteristics, low endotoxin, and low hemoglobin levels
Manufactured in our ISO 9001:2015 certified facility
Summary for Fetal Bovine Serum - Premium, Heat Inactivated
Why Use Fetal Bovine Serum - Premium, Heat Inactivated?
Fetal Bovine Serum, also known as Fetal Calf Serum (FCS), is a critical supplement added to cell culture medium to maintain cell health and promote expansion. Different grades of FBS are available from R&D Systems that address the value and premium needs of research.
All lots of Fetal Bovine Serum – Premium are sterility, virus, and performance tested, and include a biochemical profile. Lots are manufactured from USA origin or USDA-approved origin material following stringent manufacturing and quality control procedures. All lots of FBS - Premium are manufactured in our ISO 9001:2015 certified facility.
Heat Inactivation - Serum is inactivated by raising the temperature to 56 °C for 30 minutes under controlled conditions. The objective of heat inactivation is to destroy complement activity in the serum without affecting the growth-promoting characteristics of the product. Removal of complement activity from the serum is not required for most cell cultures, but may be necessary for cultures that are sensitive to the complement activity. Since heat inactivation of the serum may, to some extent, decrease the growth performance properties of the serum, this procedure should only be performed if actually required for optimal cell growth. Researchers should evaluate the applicability of heat inactivation in regards to their own application. If heat inactivation is required, the process should be carefully controlled to avoid increased formation of crystalline and flocculent precipitates, gelling of serum proteins and excessive loss of growth performance. Significant damage to serum can occur when it is subjected to higher than required temperatures or heated over extended lengths of time.
Collection, Processing, and Testing of R&D Systems FBS
Collection and Processing - R&D Systems FBS is manufactured under a process that meets USDA requirements for animal products and ensures the product is traceable back to the date and location of collection. Our FBS manufacturing adheres to closed-system collection, processing in positive pressure, HEPA-filtered clean rooms, and triple 0.1 um filtration to remove contaminants. Strict control of the process from collection through processing enables us to provide a stable, consistent performing, and traceable supply of quality serum throughout global fluctuations in serum availability and regulatory requirements.
Biochemical Testing - R&D Systems FBS undergo biochemical profiling including total protein, albumin, globulin, IgG, total bilirubin, glucose, iron, cholesterol, triglycerides, sodium and potassium. View the product insert for a complete list of biochemical profiling components, which may vary between grades.
Chemical Analysis - Each lot of FBS is tested for osmolality, pH, hemoglobin, endotoxin (LAL method) and microbiological contamination (using methods recommended by the U.S. Pharmacopeia).
Product Specifications for Fetal Bovine Serum - Premium, Heat Inactivated
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