Rat CLEC10A/CD301 (NP_071788) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1927
Key Product Details
Species
Rat
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: CLEC10A/CD301
CLEC10A, also known as MGL, CD301, DC-ASGPR, and HML, is a transmembrane C-type lectin family that is expressed on immature myleloid dendritic cells, Langerhans cells, and alternatively activated (tolerogenic) macrophages. It is upregulated on pro-inflammatory monocytes in obesity and promotes their trafficking to adipose tissue. CLEC10A selectively binds and internalizes terminal nonsialylated GalNAc moieties on O-linked carbohydrates including the Tn carcinoma antigen and carbohydrates on some CD45 isoforms. It also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.
Long Name
Macrophage Galactose N-Acetyl-Galactosamine Specific Lectin 1
Alternate Names
CD301, CLECSF14, HML2, MGL
Entrez Gene IDs
10462 (Human)
Gene Symbol
CLEC10A
UniProt
Additional CLEC10A/CD301 Products
Product Documents for Rat CLEC10A/CD301 (NP_071788) VersaClone cDNA
Product Specific Notices for Rat CLEC10A/CD301 (NP_071788) VersaClone cDNA
For research use only
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