Human Osteoprotegerin/TNFRSF11B (AAB53709) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1915
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Osteoprotegerin/TNFRSF11B
Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.
Alternate Names
OCIF, TNFRSF11B
Gene Symbol
TNFRSF11B
UniProt
Additional Osteoprotegerin/TNFRSF11B Products
Product Documents for Human Osteoprotegerin/TNFRSF11B (AAB53709) VersaClone cDNA
Product Specific Notices for Human Osteoprotegerin/TNFRSF11B (AAB53709) VersaClone cDNA
For research use only
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