Human Myocilin (NP_000252) VersaClone cDNA

Myocilin is a variably glycosylated, 65 kDa, secreted polypeptide that belongs to the family of olfactomedin-related proteins. Human Myocilin is synthesized as a 490 amino acid (aa) precursor that contains an 18 aa signal sequence, an 84 aa N-terminus containing a coiled-coil domain, a 53 aa alpha-helical leucine zipper and a 335 aa C-terminus that contains a 260 aa OLF-domain. An alternate start site generates a 504 aa mature protein without a signal sequence. Myocilin forms nondisulfide-linked dimers and multimers. The human 32 kDa OLF-domain shares 87% aa sequence identity with the OLF-domain in bovine, rat and mouse. Mutations in the OLF-domain of this protein can result in glaucoma.