Human Common beta Chain (NP_000386) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1170
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Common beta Chain
The high-affinity receptors for Interleukin-3 (IL-3), IL-5, and Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) consist of a cytokine-specific a chain, and a shared common beta chain subunit (CD131) that is essential for receptor signaling. CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective heteroreceptor complex. Phosphorylation of CD131 following receptor activation imparts growth and survival signals to the responding hematopoietic cells.
Alternate Names
CD131, CSF2RB, GM-CSF R beta, IL-3 R beta, IL-5 R beta
Gene Symbol
CSF2RB
UniProt
Additional Common beta Chain Products
Product Documents for Human Common beta Chain (NP_000386) VersaClone cDNA
Product Specific Notices for Human Common beta Chain (NP_000386) VersaClone cDNA
For research use only
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