Human CD1c/BDCA-1 (NP_001756) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1272
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: CD1c/BDCA-1
Cluster of Differentiation Antigen 1c/Blood Dendritic Cell Antigen 1 (CD1c/BDCA-1) is a transmembrane glycoprotein in the CD1 family of MHC-like molecules. It is expressed by humans but not by mice or rats. Human CD1c/BDCA-1 is a 316 amino acid protein with a predicted molecular weight of 43 kDa. It binds to lipid and glycolipid antigens and presents them to T cells. CD1c/BDCA-1 is expressed by dendritic cells and B cells, where it traffics between endosomes and the plasma membrane. Heterodimerization with beta-2-Microglobulin is required for CD1c membrane trafficking. CD1c is thought to present a wide variety of lipids to T cells and has been shown to mediate T cell activation in response to Mycobacterium tuberculosis.
Additional CD1c/BDCA-1 Products
Product Documents for Human CD1c/BDCA-1 (NP_001756) VersaClone cDNA
Product Specific Notices for Human CD1c/BDCA-1 (NP_001756) VersaClone cDNA
For research use only
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