Human Calcium-sensing R/CaSR (NP_000379) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC0311

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Key Product Details

Species

Human

Accession Number

NP_000379

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Calcium-sensing R/CaSR

Calcium-Sensing Receptor (CaSR) is a member of the G protein-coupled receptor family. CaSR is an integral membrane protein that senses changes in the extracellular concentration of calcium ions and controls the release of parathyroid hormone. The activity of the calcium-sensing receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Mutations that inactivate CaSR lead to familial hypocalciuric hypercalcemia, whereas mutations that activate CaSR cause autosomal dominant hypocalcemia. Calcium-Sensing Receptor antibodies are useful tools for parathyroid studies and research on cellular calcium homeostasis regulation.

Long Name

Calcium-sensing Receptor

Alternate Names

CAR, CaSR, EIG8, FHH, FIH, GPRC2A, HHC1, NSHPT, PCaR1

Entrez Gene IDs

846 (Human); 12374 (Mouse); 24247 (Rat)

Gene Symbol

CASR

UniProt

NP_000379

Additional Calcium-sensing R/CaSR Products

Product Documents for Human Calcium-sensing R/CaSR (NP_000379) VersaClone cDNA

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Product Specific Notices for Human Calcium-sensing R/CaSR (NP_000379) VersaClone cDNA

For research use only

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