Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

DyLight 550 (Excitation = 562 nm, Emission = 576 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 200414

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all UNC5H3 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human UNC5H3
Ala40-Asp376
Accession # O95185

Specificity

Detects human UNC5H3 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human UNC5H4 or recombinant rat UNC5H2 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for UNC5H3/UNC5C Antibody (200414) [DyLight 550]

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: UNC5H3

UNC5C is a gene that codes for a protein that is the receptor for netrin that is required for axon guidance, as it mediates the axon repulsion of neuronal growth cones when there is ligand binding in the nervous system, and can also help to induce apoptosis. The protein encoded by UNC5C has two isoforms, with lengths of 931 and 597 amino acids and weights of approximately 103 and 66 kDa respectively. Current studies are being done on diseases and disorders related to this gene including colorectal cancer, renal cell carcinoma, rheumatoid arthritis, Parkinson's disease, kidney cancer, colon cancer, osteoarthritis, schizophrenia, and neuronitis. UNC5C has also been shown to have interactions with NTN1, PTPN11, DAPK1, DCC, and FYN in pathways such as the netrin signaling and axon guidance pathways.

Long Name

Netrin Receptor UNC5C

Alternate Names

UNC5C

Gene Symbol

UNC5C

Additional UNC5H3 Products

Product Documents for UNC5H3/UNC5C Antibody (200414) [DyLight 550]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for UNC5H3/UNC5C Antibody (200414) [DyLight 550]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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