SOCS-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-781

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NB100-781
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (100%), Canine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all SOCS-1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-VLRDYLSSFPFQI corresponding to C-Terminus according to NP_003736.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for SOCS-1 Antibody

Immunocytochemistry/ Immunofluorescence: SOCS-1 Antibody [NB100-781]

Immunocytochemistry/ Immunofluorescence: SOCS-1 Antibody [NB100-781]

Immunocytochemistry/Immunofluorescence: SOCS-1 Antibody [NB100-781] - Immunofluorescence analysis of paraformaldehyde fixed MCF7 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing cytoplasmic and nuclear staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).
Immunohistochemistry-Paraffin: SOCS-1 Antibody [NB100-781]

Immunohistochemistry-Paraffin: SOCS-1 Antibody [NB100-781]

Immunohistochemistry-Paraffin: SOCS-1 Antibody [NB100-781] - Negative Control showing staining of paraffin embedded Mouse Kidney, with no primary antibody.
Flow Cytometry: SOCS-1 Antibody [NB100-781]

Flow Cytometry: SOCS-1 Antibody [NB100-781]

Flow Cytometry: SOCS-1 Antibody [NB100-781] - Flow cytometric analysis of paraformaldehyde fixed HEK293 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (1 ug/mL). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
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Applications for SOCS-1 Antibody

Application
Recommended Usage

Flow Cytometry

10 ug/mL

Immunocytochemistry/ Immunofluorescence

10 ug/mL

Immunohistochemistry

5 - 10 ug/mL

Immunohistochemistry-Paraffin

5 - 10 ug/mL

Peptide ELISA

Detection limit 1:4000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SOCS-1

Cytokines induce a variety of biologic responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways. Proteins that mediate these signals from the cell surface to the nucleus include Janus kinases, e.g., Janus kinase-1, and the signal transducers and activators of transcription (STATs), such as STAT1. To maintain tight control of these signal transduction pathways, mechanisms for turning off the signals are necessary. The adverse consequences of an imbalance between positive and negative signals is evident in the 'motheaten' mouse, which lacks the phosphatase SHP1. These mice fail to regulate cytokine responses appropriately, resulting in hyperproliferation and accumulation of cells in several hematopoietic lineages and the development of systemic autoimmune disease. SOCS1 represents a family of proteins that regulates responses to cytokines. SOCS1 (also known as Janus kinase-binding protein and STAT-induced STAT inhibitor-1) was isolated independently by its ability to interact with Janus kinase-2 in a 2-hybrid screen and on the basis of antigenic similarity with the SH2 domain of STAT3. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine-inducible SH2-containing protein).

Long Name

Suppressor Of Cytokine Signaling 1

Alternate Names

CIS1, Cish1, JAB, SOCS1, SSI-1, TIP3

Entrez Gene IDs

8651 (Human); 12703 (Mouse)

Gene Symbol

SOCS1

UniProt

O15524 (Human)

Additional SOCS-1 Products

Product Documents for SOCS-1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SOCS-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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