PTEN [p Ser380] Antibody (2E8X8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16911

Recombinant Monoclonal Antibody
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NBP3-16911-100ul
NBP3-16911-20ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 2E8X8 expressed in HEK293

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PTEN Antibodies »

Product Specifications

Immunogen

A synthetic phosphorylated peptide around S380 of human PTEN (P60484). RYSDT

Modification

p Ser 380

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PTEN [p Ser380] Antibody (2E8X8)

Western Blot: PTEN [p Ser380] Antibody (2E8X8) [NBP3-16911] - Western blot analysis of extracts of 293T cells, using PTEN Rabbit mAb (NBP3-16911) at 1:1000 dilution.293T cells were treated by CIP(20uL/400ul) at 37C for 1 hour. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit. Exposure time: 3min.

Applications for PTEN [p Ser380] Antibody (2E8X8)

Application
Recommended Usage

Western Blot

1:500 - 1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.3), 50% glycerol, 0.05% BSA

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PTEN

PTEN is a protein tyrosine phosphatase that acts as a tumor suppressor, as a lipid phosphatase that dephosphorylates the D3 position of phosphatidylinositol 3,4,5-trisphosphate and as an antagonist of the PI3k/AKT signaling pathway (1-3). PTEN structural domains includes an N-terminal phosphatase domain, a lipid binding C2 domain and a 50-amino acid C-terminal tail that contains a PD biding sequence (5). Phosporylation of the tail of the protein will suppress its activity and modify its conformation to a

Long Name

Phosphatase and Tensin Homolog Deleted on Chromosome 10

Alternate Names

MMAC1

Gene Symbol

PTEN

Additional PTEN Products

Product Documents for PTEN [p Ser380] Antibody (2E8X8)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PTEN [p Ser380] Antibody (2E8X8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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