PML Protein Antibody (SR1825) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21728

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21728-100ul
NBP3-21728-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1825 expressed in HEK293

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PML Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human PML Protein (Uniprot #: P29590)

Specificity

Detects endogenous levels of total PML Protein

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit PML Protein Antibody (SR1825) - BSA Free (NBP3-21728) is a recombinant monoclonal antibody validated for use in IHC, WB, Flow, ICC/IF and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for PML Protein Antibody (SR1825) - BSA Free

Western Blot: PML Protein Antibody (SR1825) [NBP3-21728] -

Western Blot: PML Protein Antibody (SR1825) [NBP3-21728] - Western blot analysis using NBP3-21728 in 293 cell lysate.

Applications for PML Protein Antibody (SR1825) - BSA Free

Application
Recommended Usage

Flow Cytometry

1:200

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:100-1:500

Immunoprecipitation

1:50

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PML

PML Protein is encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Long Name

Promyelocytic Leukemia

Alternate Names

MYL, RNF71, TRIM19

Gene Symbol

PML

Additional PML Products

Product Documents for PML Protein Antibody (SR1825) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PML Protein Antibody (SR1825) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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