PKR [p Thr451] Antibody (23GB1710)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51810

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NBP3-51810-100ul
NBP3-51810-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB1710

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PKR Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Phospho-Phospho-PKR (T451) (Uniprot: P19525)

Modification

p Thr451

Specificity

This antibody detects endogenous levels of EIF2AK2 only when phosphorylated at T451

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PKR [p Thr451] Antibody (23GB1710)

PKR [p Thr451] Antibody (23GB1710)

Immunocytochemistry/ Immunofluorescence: PKR [p Thr451] Antibody (23GB1710)[NBP3-51810] -

Immunocytochemical staining of HT-1080 cells with PKR antibody (1:1,000). Nuclei were stained blue with DAPI; PKR was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
PKR [p Thr451] Antibody (23GB1710)

Western Blot: PKR [p Thr451] Antibody (23GB1710)[NBP3-51810] -

Western blotting analysis using PKR (T451) antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for PKR [p Thr451] Antibody (23GB1710)

Application
Recommended Usage

Flow Cytometry

1:200-1:2,000

Immunocytochemistry/ Immunofluorescence

1:100-1:1,000

Western Blot

1:1,000-1:5,000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PKR

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses.

Long Name

Protein Kinase R

Alternate Names

EIF2AK2, P68 Kinase, PPP1R83, PRKR, Protein Kinase R

Gene Symbol

EIF2AK2

Additional PKR Products

Product Documents for PKR [p Thr451] Antibody (23GB1710)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PKR [p Thr451] Antibody (23GB1710)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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