Paxillin [p Tyr118] Antibody (24GB900)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51464

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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB900

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Paxillin Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Phospho-Paxillin (Y118) (Uniprot: P49023)

Modification

p Tyr118

Specificity

This antibody detects endogenous levels of PXN only when phosphorylated at Y118

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Paxillin [p Tyr118] Antibody (24GB900)

Paxillin [p Tyr118] Antibody (24GB900)

Immunocytochemistry/ Immunofluorescence: Paxillin [p Tyr118] Antibody (24GB900)[NBP3-51464] -

Immunocytochemical staining of Hela cells with Paxillin antibody (1:1,000) . Nuclei were stained blue with DAPI; Paxillin was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 um.

Applications for Paxillin [p Tyr118] Antibody (24GB900)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Paxillin

Paxillin is a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion) (1). Paxillin plays a significant role in integrin signaling and the tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization (2). Paxillin is phosphorylated by focal adhesion kinase (FAK) at Tyr118 (3). It has been found that phosphorylation of paxillin at both Tyr118 and Tyr31 is essential for MM1 cancer cell migration (4).

Alternate Names

PXN

Gene Symbol

PXN

Additional Paxillin Products

Product Documents for Paxillin [p Tyr118] Antibody (24GB900)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Paxillin [p Tyr118] Antibody (24GB900)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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