Key Product Details

Species Reactivity

Mouse, Rat

Applications

Blockade of Receptor-ligand Interaction, CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot

Label

Janelia Fluor 646

Antibody Source

Polyclonal Goat IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Neuropilin-1 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant rat Neuropilin-1
Phe22-Ala810 (Lys811Arg), Ser829-Asp854
Accession # Q9QWJ9

Specificity

Detects mouse and rat Neuropilin-1 in direct ELISAs and Western blots. In direct ELISAs less than 1% cross-reactivity with recombinant rat Neuropilin-2 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Neuropilin-1 Antibody [Janelia Fluor® 646]

Application
Recommended Usage

Blockade of Receptor-ligand Interaction

Optimal dilutions of this antibody should be experimentally determined.

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Neuropilin-1

Neuropilin-1/CD304 is a type-I transmembrane protein. It forms a heterodimeric complex with vascular endothelial growth factor receptor 2, and this complex functions as a receptor for vascular endothelial growth factor. On the other hand, Neuropilin-1/CD304 forms a complex with plexin-1, and this complex acts as a semaphorin 3A receptor. Neuropilin-1/CD304 is involved in angiogenesis, axon guidance, cell survival, migration, and invasion. Recently, it has been reported that Neuropilin-1/CD304 is an essential component located on the immunological synapse and acts as a potent cell-surface marker for murine regulatory T cells (Treg). Neuropilin-1/CD304 expressed by Treg cells promotes long interactions between Treg cells and immature dendritic cells and restricts access of effector cells to the antigen-presenting cells.

Alternate Names

BDCA-4, CD304, Neuropilin1, NRP1

Gene Symbol

NRP1

Additional Neuropilin-1 Products

Product Documents for Neuropilin-1 Antibody [Janelia Fluor® 646]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Neuropilin-1 Antibody [Janelia Fluor® 646]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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