Mouse GPVI PE-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB6758P
Conjugate
Catalog #
Key Product Details
Species Reactivity
Validated:
Mouse
Cited:
Mouse
Applications
Validated:
Flow Cytometry
Cited:
Flow Cytometry
Label
Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)
Antibody Source
Monoclonal Rat IgG1 Clone # 784808
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse GPVI
Gly24-Lys265
Accession # P0C191
Gly24-Lys265
Accession # P0C191
Specificity
Detects mouse GPVI in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human GPVI is observed.
Clonality
Monoclonal
Host
Rat
Isotype
IgG1
Scientific Data Images for Mouse GPVI PE-conjugated Antibody
Detection of GPVI in Mouse Platelets by Flow Cytometry.
Mouse platelets were stained with Rat Anti-Mouse GPVI PE-conjugated Monoclonal Antibody (Catalog # FAB6758P, filled histogram) or isotype control antibody (Catalog # IC005P, open histogram). View our protocol for Staining Membrane-associated Proteins.Applications for Mouse GPVI PE-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
10 µL/106 cells
Sample: Mouse platelets
Sample: Mouse platelets
Spectra Viewer
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectra Viewer
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
Background: GPVI
GPVI (Platelet Glycoprotein VI), also known as Glycoprotein 5, is a member of the Ig superfamily. It is found on platelets and megakaryocytes, and serves as the main collagen receptor on platelets. Following exposure to subendothelial connective tissue, GPVI binds to a Gly-Pro-(hydroxy)Pro motif on collagen and generates a noncovalent membrane signaling complex with FcR gamma-chain. This interaction is stabilized by Integrin alpha2 beta1, followed by activation of PLC gamma2 with clot initiation. Mature mouse GPVI is a 292 amino acid (aa) type I transmembrane protein. It possesses a 244 aa extracellular region (aa 22-265) that contains two C2-type Ig-like domains (aa 27-197)and two potential glycosylation sites, plus a 37 aa cytoplasmic tail (aa 287-313). There is one potential splice form that shows a deletion of aa 224-240. Over aa 24-265, mouse GPVI shares 70% and 86% aa identity with human and rat GPVI, respectively.
Long Name
Glycoprotein VI [Platelet]
Alternate Names
GP6
Gene Symbol
GP6
UniProt
Additional GPVI Products
Product Documents for Mouse GPVI PE-conjugated Antibody
Product Specific Notices for Mouse GPVI PE-conjugated Antibody
For research use only
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