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Mer Antibody (23GB2070)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-50993

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NBP3-50993-100ul
NBP3-50993-20ul

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB2070

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

A synthesized peptide derived from human Mer (Uniprot: Q12866)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Mer Antibody (23GB2070)

Mer Antibody (23GB2070)

Immunocytochemistry/ Immunofluorescence: Mer Antibody (23GB2070)[NBP3-50993] -

Immunocytochemical staining of HAP-1 cells with Mer antibody (1:1,000). Nuclei were stained blue with DAPI; Mer was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
Mer Antibody (23GB2070)

Flow Cytometry: Mer Antibody (23GB2070)[NBP3-50993] -

Flow cytometric analysis of Merexpression in HAP-1 cells using Mer antibody (1:2,000). Green, isotype control; red, MERTK.
Mer Antibody (23GB2070)

Western Blot: Mer Antibody (23GB2070)[NBP3-50993] -

Western blotting analysis using Mer antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for Mer Antibody (23GB2070)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Mer

MerTK (c-mer, Nyk, Eyk) is a tyrosine kinase that belongs to a family of transmembrane receptors (1). MerTk has been implicated in reversible cell growth arrest, survival, proliferation and cell adhesion. Growth arrest specific protein 6 (Gas6) is an activating ligand for MerTK (2-3). MerTK is required for clearance of apoptotic cells by mononuclear phagocytes in mice; with its absence resulting in progressive lupus like autoimmunity (4). Defects in MERTK are a cause of retinitis pigmentosa (RP) (5).

Long Name

Receptor Tyrosine Protein Kinase Mer

Alternate Names

c-Eyk, C-mer, MerTK

Gene Symbol

MERTK

Additional Mer Products

Product Documents for Mer Antibody (23GB2070)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Mer Antibody (23GB2070)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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