M-CSFR/CD115 Antibody (PD00-45)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-32227

Recombinant Monoclonal Antibody
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NBP3-32227
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # PD00-45 expressed in HEK293

Concentration

1 mg/ml

View all M-CSF R/CD115 Antibodies »

Product Specifications

Immunogen

Recombinant protein within human M-CSFR/CD115 aa 539-972 (Cytoplasmic) (Uniprot: P07333)

Localization

Cell membrane

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

108 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for M-CSFR/CD115 Antibody (PD00-45)

M-CSFR/CD115 Antibody (PD00-45)

Immunohistochemistry: M-CSFR/CD115 Antibody (PD00-45) [NBP3-32227]

Immunohistochemistry: M-CSFR/CD115 Antibody (PD00-45) [NBP3-32227] - Immunohistochemical analysis of paraffin-embedded human tonsil tissue with Rabbit anti-M-CSFR/CD115 antibody (NBP3-32227) at 1/10,000 dilution.

The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (NBP3-32227) at 1/10,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

Applications for M-CSFR/CD115 Antibody (PD00-45)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH7.4), 0.1% BSA and 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: M-CSF R/CD115

MCSF Receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.

Long Name

Macrophage Colony Stimulating Factor Receptor

Alternate Names

c-fms, CD115, CSF1R, M-CSFR, MCSFR

Gene Symbol

CSF1R

Additional M-CSF R/CD115 Products

Product Documents for M-CSFR/CD115 Antibody (PD00-45)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for M-CSFR/CD115 Antibody (PD00-45)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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