Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

DyLight 650 (Excitation = 652 nm, Emission = 672 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 135105

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Lymphotoxin beta/TNFSF3 Antibodies »

Product Specifications

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Lymphotoxin  alpha/ beta

Specificity

Detects human Lymphotoxin alpha beta heterotrimers in direct ELISAs and Western blots. This antibody detects an epitope in the Lymphotoxin  beta subunit. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) Lymphotoxin  alpha, rhAPRIL, rhBAFF, rhTNF‑ alpha, rhTWEAK, rhEDA‑A2, rhEDA, rhTRAIL, rhVEGI, rhTRANCE, rhFas Ligand, or rhOX40 Ligand.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Lymphotoxin beta/TNFSF3 Antibody (135105) [Dylight 650]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Lymphotoxin beta/TNFSF3

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha, also known as TNF beta) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. LT-beta (lymphotaxin-beta or tumor necrosis factor C) is a type II membrane protein with significant homology to TNF, LT-alpha, and the ligand for the CD40 receptor. LT-alpha is present on the surface of activated T, B, and LAK cells as a complex with the 33 kda glycoprotein, LT-beta. LT-beta, also expressed by active lymphocytes, forms a heterotrimer with LT-a on the cell surface and anchors LT-alpha to the cell surface. A TNF receptor-related protein, the LT-beta receptor (also known as TNFC receptor), is the human receptor for the LT-alpha/LT-beta heterotrimer. There are two LT-beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas. The gene which encodes LT-beta maps to the major histocompatibility complex region on human chromosome 6p21.3.

Long Name

Lymphotoxin beta

Alternate Names

LTB, TNFSF3

Gene Symbol

LTB

Additional Lymphotoxin beta/TNFSF3 Products

Product Documents for Lymphotoxin beta/TNFSF3 Antibody (135105) [Dylight 650]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Lymphotoxin beta/TNFSF3 Antibody (135105) [Dylight 650]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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