Klotho beta Antibody [Janelia Fluor® 646]
Novus Biologicals, part of Bio-Techne | Catalog # AF5889J
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot, Immunocytochemistry
Label
Janelia Fluor 646
Antibody Source
Polyclonal Goat IgG
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Klotho beta
Phe53-Leu997
Accession # Q86Z14
Phe53-Leu997
Accession # Q86Z14
Specificity
Detects human Klotho beta in direct ELISAs and Western blots. In direct ELISAs, approximately 35% cross-reactivity with recombinant mouse Klotho beta is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications for Klotho beta Antibody [Janelia Fluor® 646]
Application
Recommended Usage
Immunocytochemistry
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Klotho beta
Klotho beta is expressed primarily in the liver and pancreas and functions as a cofactor for FGF-19 subfamily member interactions with their receptors. It facilitates human FGF-19 (mouse FGF-15) binding to FGF R4 in the liver to inhibit bile acid synthesis. It also enhances FGF-21 binding to FGF R1c in adipocytes, leading to increased Insulin-dependent glucose uptake.
Alternate Names
KLB
Gene Symbol
KLB
Additional Klotho beta Products
Product Documents for Klotho beta Antibody [Janelia Fluor® 646]
Product Specific Notices for Klotho beta Antibody [Janelia Fluor® 646]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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