Integrin alpha 2 beta 1 Antibody [DyLight 650] - (Research Grade vatelizumab Biosimilar)
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28512C
Recombinant Monoclonal Antibody
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Human
Applications
ELISA, Flow Cytometry, Functional
Label
DyLight 650 (Excitation = 652 nm, Emission = 672 nm)
Antibody Source
Recombinant Monoclonal Human IgG4 expressed in CHO
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Integrin a2b1 (ITGA2 & ITGB1)
Clonality
Monoclonal
Host
Human
Isotype
IgG4
Description
The heavy chain type is huIgG4SP, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.
Also known as 'vatelizumab'.
IgG4SP is human IgG4 with S228P mutation.
Also known as 'vatelizumab'.
IgG4SP is human IgG4 with S228P mutation.
Applications
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Functional
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Integrin alpha 2 beta 1
Integrin alpha 2 beta 1 (VLA-2) is one of twelve Integrin family adhesion receptors that share the beta 1 subunit. It is one of six very late antigens expressed on activated T cells. Divalent cations and intracellular (inside-out) signaling convert it to its most active, extended, and open conformation. alpha 2 beta 1 binds to Collagen types I, II, and III, Laminin, Decorin, E-Cadherin, and Collectin molecules such as C1q. Platelet a2b1, also called GPIa, cooperates with GPVI to coordinate platelet collagen binding and activation. Adhesion is enhanced by crosstalk with Syndecan-1 or HGF R/c-Met and antagonized by crosstalk with Integrin a1b1. a2b1 is additionally expressed on select hematopoietic and non-hematopoietic cells.
Alternate Names
alpha 2 integrin, alpha 2 subunit of VLA-2 receptor, BR, CD49 antigen-like family member B, CD49b, collagen receptor, glycoprotein Ia, GPIa, HPA-5, human platelet alloantigen 5, human platelet alloantigen system 5, integrin alpha-2, integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), platelet antigen Br, platelet glycoprotein GPIa, platelet membrane glycoprotein Ia, very late activation protein 2 receptor, alpha-2 subunit, very late activation receptor alpha-2 subunit, very late activation receptor subunit alpha-2, VLA-2, VLAA2
Additional Integrin alpha 2 beta 1 Products
Product Specific Notices
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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