IFN-alpha/beta R1 Antibody (DMC221) - Chimeric

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-48295

Recombinant Monoclonal Antibody
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NBP3-48295-100ug
NBP3-48295-10ug
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # DMC221

Concentration

LYOPH mg/ml

View all IFN-alpha/beta R1 Antibodies »

Product Specifications

Immunogen

IFN-alpha/beta R1 recombinant protein expressed in mammalian cells (Accession# P17181). The exact amino acid sequence is proprietary.

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Description

This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).

Scientific Data Images for IFN-alpha/beta R1 Antibody (DMC221) - Chimeric

IFN-alpha/beta R1 Antibody (DMC221) - Chimeric

Flow Cytometry: IFN-alpha/beta R1 Antibody (DMC221) - Chimeric [NBP3-48295]

Flow cytometry analysis with Anti-IFN-alpha/beta R1 (DMC221) on HEK293 cells transfected with human IFN-alpha/beta R1 (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).

Applications for IFN-alpha/beta R1 Antibody (DMC221) - Chimeric

Application
Recommended Usage

ELISA

1:5000-10000

Flow Cytometry

1:100

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified from cell culture supernatant

Reconstitution

Dissolve the lyophilized antibody in sterile and low endotoxin water. The recommend volume of water is lot specific. Please refer to the instructions printed on the product vial or contact technical support.

Formulation

PBS, pH 7.4, 5-8% Trehalose

Preservative

Trehalose

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Background: IFN-alpha/beta R1

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Long Name

Interferon alpha/beta Receptor 1

Alternate Names

IFN-aR1, IFN-bR1, IFNAR1, IFNbR1

Gene Symbol

IFNAR1

Additional IFN-alpha/beta R1 Products

Product Documents for IFN-alpha/beta R1 Antibody (DMC221) - Chimeric

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for IFN-alpha/beta R1 Antibody (DMC221) - Chimeric

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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