TMPRSS2 is a transmembrane serine protease. The TMPRSS2 gene is upregulated by androgenic hormones in prostate cells and downregulated in androgen-independent prostate cancer. The fusion between TMPRSS2 gene and ERG is the most common chromosomal aberration detected in prostate cancer. In relation to COVID-19, TMPRSS2 is involved in priming the viral spike protein which facilitates viral entry. TMPRSS2 inhibitors are candidates for treatment options of SARS-CoV-2 and other coronaviruses.

Long Name

Transmembrane protease, serine 2

Alternate Names

Epitheliasin, PP9284, PRSS10

Entrez Gene IDs

7113 (Human); 50528 (Mouse); 102137447 (Cynomolgus Monkey)

Gene Symbol

TMPRSS2

UniProt

O15393 (Human)

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SDS

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Product Specific Notices

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Flow Cytometry

Human TMPRSS2 Alexa Fluor™ Plus 405-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB10723AFP405

Key Product Details

Species Reactivity

Applications

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Antibody Source

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Product Specifications

Immunogen

Specificity

Clonality

Host

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Applications

Flow Cytometry

Immunocytochemistry

Formulation, Preparation, and Storage

Formulation

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Stability & Storage

Background: TMPRSS2