Human TGF-beta RII APC-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB2411A
Scientific images may be resized, cropped, or adjusted for brightness or contrast for presentation purposes. These updates are limited to presentation and do not affect the underlying scientific interpretation of the data. Where available, additional source data may be provided upon request.
Conjugate
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human, Mouse
Applications
Validated:
Flow Cytometry
Cited:
Flow Cytometry
Label
Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)
Antibody Source
Polyclonal Goat IgG
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TGF-beta RII
Ile24-Asp159
Accession # P37173.2
Ile24-Asp159
Accession # P37173.2
Specificity
Detects human TGF-beta RII in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse (rm) TGF‑ beta RII and less than 1% cross-reactivity with recombinant human TGF-beta RIII and rmTGF-beta RI is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Scientific Data Images for Human TGF-beta RII APC-conjugated Antibody
Detection of TGF-beta RII in Human Blood Lymphocytes by Flow Cytometry.
Human peripheral blood lymphocytes were stained with Goat Anti-Human TGF-beta RII APC-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB2411A, filled histogram) or isotype control antibody (Catalog # IC108A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Detection of Human TGF-beta RII by Flow Cytometry
Extrafacial expression of T betaRII on malignant breast cancer cell-derived EVs&its regulation by TGF-beta. f FACS analysis&quantification of the %age of T betaRII positive (T betaRII+) EVs from different breast cancer cell lines (left panel). n = 3 biological replicates per group (right panel). The %age was referred to as the %age of beads with T betaRII+ EVs. Image collected & cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/35915084), licensed under a CC-BY license. Not internally tested by R&D Systems.Applications for Human TGF-beta RII APC-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
10 µL/106 cells
Sample: Human peripheral blood lymphocytes
Sample: Human peripheral blood lymphocytes
Reviewed Applications
Read 1 review rated 4 using FAB2411A in the following applications:
Spectra Viewer
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectra Viewer
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TGF-beta RII
TGF betaRII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF beta RII interacts with TGF betaRI to form the heteromeric signaling complex thattransduces TGF beta signals. A splice variant of the type II receptor, TGF betaRIIb, containing a 25 amino acid residue insertion near the Nterminus of the mature protein has also been described.
Long Name
Transforming Growth Factor beta Receptor II
Alternate Names
TGF-bRII, TGFbetaRII, TGFBR2
Gene Symbol
TGFBR2
UniProt
Additional TGF-beta RII Products
Product Documents for Human TGF-beta RII APC-conjugated Antibody
Product Specific Notices for Human TGF-beta RII APC-conjugated Antibody
For research use only
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