Human Presenilin-2 C-Terminal Fragment Antibody
R&D Systems, part of Bio-Techne | Catalog # AF197
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Unconjugated
Antibody Source
Polyclonal Goat IgG
Product Specifications
Immunogen
E. coli-derived recombinant human Presenilin‑2 C-Terminal Fragment
Glu322-Thr388
Accession # P49810
Glu322-Thr388
Accession # P49810
Specificity
Detects human Presenilin‑2 C-Terminal Fragment in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross‑reactivity with recombinant human (rh) Presenilin‑1 N‑Terminal Fragment (aa 1‑80), rhPresenilin‑1 C‑Terminal Fragment (aa 298‑407), and rhPresenilin‑2 N‑Terminal Fragment (aa 1‑80) is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications for Human Presenilin-2 C-Terminal Fragment Antibody
Application
Recommended Usage
Western Blot
0.1 µg/mL
Sample: Recombinant Human Presenilin‑2 C‑Terminal Fragment
Sample: Recombinant Human Presenilin‑2 C‑Terminal Fragment
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Presenilin-2
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.
Additional Presenilin-2 Products
Product Documents for Human Presenilin-2 C-Terminal Fragment Antibody
Product Specific Notices for Human Presenilin-2 C-Terminal Fragment Antibody
For research use only
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