Human ORF73 HHV8 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB10389

R&D Systems, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG Clone # LN53

View all ORF73 HHV8 Antibodies »

Product Specifications

Immunogen

Recombinant protein corresponding to the latent nuclear antigen-1 molecule of ORF73 HHV8

Specificity

Detects human ORF73 HHV8 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for Human ORF73 HHV8 Antibody

ORF73 HHV8 antibody in Kaposi's Sarcoma Skin Tissue by Immunohistochemistry (IHC-P).

ORF73 HHV8 in Kaposi's Sarcoma Skin Tissue.

ORF73 HHV8 was detected in immersion fixed paraffin-embedded sections of Kaposi's Sarcoma skin tissue using Mouse Anti-Human ORF73 HHV8 Monoclonal Antibody (Catalog # MAB10389) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC005). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell nuclei. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Applications for Human ORF73 HHV8 Antibody

Application
Recommended Usage

Immunohistochemistry

5-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of Kaposi's Sarcoma skin tissue

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ORF73 HHV8

Lana1 (also known as ORF73 or HHV8)  is a multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Lana1 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for Lana1 in kaposi's sarcoma.

Long Name

ORF73 of Human Herpesvirus 8

Alternate Names

HHV8GK18_gp81, LANA1

Entrez Gene IDs

4961527 (Viral)

Gene Symbol

HHV8GK18_GP81

Additional ORF73 HHV8 Products

Product Documents for Human ORF73 HHV8 Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human ORF73 HHV8 Antibody

For research use only

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