Human LINGO-2 APC-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB36791A

R&D Systems, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 382007

View all LINGO-2 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human LINGO-2
Cys28-Leu542
Accession # Q7L985

Specificity

Detects human LINGO-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human LINGO-1 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Human LINGO-2 APC-conjugated Antibody

Detection of LINGO-2 antibody in HEK293 Human Cell Line Transfected with Human LINGO-2 and eGFP antibody by Flow Cytometry.

Detection of LINGO‑2 in HEK293 Human Cell Line Transfected with Human LINGO-2 and eGFP by Flow Cytometry.

HEK293 human embryonic kidney cell line transfected with either (A) human LINGO-2 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Human LINGO-2 APC-conjugated Monoclonal Antibody (Catalog # FAB36791A). Quadrant markers were set based on control antibody staining (Catalog # IC003A). View our protocol for Staining Membrane-associated Proteins.

Applications for Human LINGO-2 APC-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: HEK293 human embryonic kidney cell line transfected with human LINGO-2 and eGFP

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: LINGO-2

Human LINGO-2 (LRR and Ig domain-containing, Nogo Receptor-interacting protein 2), also known as Leucine-Rich Repeat Neuronal 6C (LRRN6C) or LERN3), type I transmembrane protein in the neuronal leucine-rich repeat family. These proteins have a signal peptide, 12 extracellular leucine-rich repeats flanked by N-terminal and C-terminal cysteine-rich sequences, an immunoglobulin-like domain, a transmembrane domain and a short cytoplasmic tail.  An alternate start site may exist at Met148 of the precursor. Human LINGO-2 is a highly conserved, 606 amino acid (aa) protein that shares 99% and 98% aa sequence identity with canine and mouse LINGO-2, respectively. LINGO-2 presumably functions outside the CNS with little involvement by p75/NgR1.

Long Name

Leucine-rich Repeat And Ig Domain Containing Nogo Receptor-Interacting Protein 2

Alternate Names

LERN3, LINGO2, LRRN6C

Entrez Gene IDs

158038 (Human); 242384 (Mouse); 313156 (Rat)

Gene Symbol

LINGO2

UniProt

Q7L985

Additional LINGO-2 Products

Product Documents for Human LINGO-2 APC-conjugated Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human LINGO-2 APC-conjugated Antibody

For research use only

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