Human CD28 GMP Antibody GMP

Key Product Details

Product Specifications

Applications for Human CD28 GMP Antibody

Formulation, Preparation, and Storage

Background: CD28

The Bio-Techne CD28 GMP antibody is derived from the 15e8 clone. CD28 is a critical protein expressed on the surface of T cells that provides a co-stimulatory signal necessary for T cell activation and proliferation. CD28 is structurally similar to CTLA-4, with both molecules exhibiting structural homology to the immunoglobulin (Ig) gene superfamily. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant co-stimulatory pathways that regulate T and B cell responses. Both CD28 and CTLA-4 are composed of a single Ig V-like extracellular domain, a transmembrane domain, and an intracellular domain. CD28 and CTLA-4 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2.

Additional CD28 Products

• All Products for CD28
• CD28 cDNA Clones
• CD28 ELISA Kits
• CD28 Lysates
• CD28 Primary Antibodies
• CD28 Proteins and Enzymes
• CD28 Simple Plex

Manufacturing Specifications

GMP Antibodies
R&D Systems, a Bio-Techne Brand's GMP Antibodies are produced according to relevant sections of the following documents: USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products, and Eu. Ph. 5.2.12, Raw Materials of Biological Origin for the Production of Cell-based and Gene Therapy Medicinal Products.
R&D Systems' quality focus includes:

• Manufactured and tested under an ISO 9001:2015 and ISO 13485:2016 certified quality system
• Documented processes and QA control of documentation and process changes
• Personnel training programs
• Raw material inspection and supplier qualification/monitoring
• Fully validated equipment, processes and test methods
• Equipment calibration monitored and scheduled using a computerized calibration program
• Facility maintenance, safety programs and pest control
• Variances dispositioned using material review process
• Robust product stability program

R&D Systems strives to provide our customers with the analytical characteristics of each product so that customers may determine whether our products are appropriate for their research. The Certificate of Analysis provided contains the following lot specific information:

• Purity (SDS-PAGE)
• Aggregation (SEC)
• Endotoxin (LAL method, tested per USP<85> and Ph. Eur. 2.6.14 guidelines)
• Residual Host Cell Protein and Host Cell DNA
• Mycoplasma testing
• Post-bottling lot-specific bioassay results (compliance with an established range) and results of microbial testing according to USP <71>

Additional testing and documentation requested by the customer can be arranged at an additional cost.
Production records and facilities are available for examination by appropriate personnel on-site at R&D Systems in Minneapolis, Minnesota USA.
R&D Systems sells GMP grade products for preclinical or clinical ex vivo use. They are not for in vivo use. Please read the following End User Terms prior to using this product.