Granzyme B Antibody (rGZMB/6740)
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-49121
Recombinant Monoclonal Antibody
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Label
Unconjugated
Antibody Source
Recombinant Monoclonal Mouse IgG1 kappa Clone # rGZMB/6740 expressed in CHO
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary) (Uniprot: P10144)
Localization
Cytolytic granule, Secreted
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Description
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody with azide - store at 2 to 8 C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody with azide - store at 2 to 8 C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Scientific Data Images for Granzyme B Antibody (rGZMB/6740)
Immunohistochemistry-Paraffin: Granzyme B Antibody (rGZMB/6740) [NBP3-49121] -
Formalin-fixed, paraffin-embedded human spleen stained with Granzyme B Antibody (rGZMB/6740).
Immunohistochemistry-Paraffin: Granzyme B Antibody (rGZMB/6740) [NBP3-49121] -
Formalin-fixed, paraffin-embedded human tonsil stained with Granzyme B Antibody (rGZMB/6740).Applications for Granzyme B Antibody (rGZMB/6740)
Application
Recommended Usage
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
10 mM PBS with 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C.
Background: Granzyme B
Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat.
Alternate Names
CGL-1, CGL1, CSPB, CTLA-1, CTLA1, CTSGL1, Fragmentin-2, Granzyme-2, GRB, GrzB, GZMB, HLP, SECT
Gene Symbol
GZMB
Additional Granzyme B Products
Product Documents for Granzyme B Antibody (rGZMB/6740)
Product Specific Notices for Granzyme B Antibody (rGZMB/6740)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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