EDA/Ectodysplasin Antibody (DMC388) - Chimeric

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-48320

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-48320-10ug
NBP3-48320-100ug
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # DMC388

Concentration

LYOPH mg/ml

View all EDA/Ectodysplasin Antibodies »

Product Specifications

Immunogen

EDA/Ectodysplasin recombinant protein expressed in mammalian cells (Accession# Q92838). The exact amino acid sequence is proprietary.

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Description

This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).

Applications for EDA/Ectodysplasin Antibody (DMC388) - Chimeric

Application
Recommended Usage

Flow Cytometry

1:100

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified from cell culture supernatant

Reconstitution

.

Formulation

PBS, pH 7.4, 5-8% Trehalose

Preservative

Trehalose

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Background: EDA/Ectodysplasin

Ectodysplasin (EDA) is a type II transmembrane protein belonging to the TNF superfamily. It can be expressed as eight alternatively spliced isoforms that are encoded by the EDA gene. Isoforms of EDA are expressed in cells of ectodermal origin, where they are localized to the cell surface and can be released in a soluble form following cleavage by Furin. The EDA-A1 and EDA-A2 splice variants differ by the deletion of two amino acids in the extracellular domain of EDA-A2. Despite this minor difference, EDA-A1 and EDA-A2 display strong receptor specificity. EDA-A1 binds to EDAR, whereas EDA-A2 binds to XEDAR. EDA-A1 and EDA-A2 are required during development, and loss or mutation of EDA results in abnormal development of hair follicles, sweat glands, and teeth. Mutations in the EDA gene are associated with a group of developmental disorders identified as ectodermal dysplasia type 1.

Alternate Names

Tabby, XHED, XLHED

Gene Symbol

EDA

Additional EDA/Ectodysplasin Products

Product Documents for EDA/Ectodysplasin Antibody (DMC388) - Chimeric

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for EDA/Ectodysplasin Antibody (DMC388) - Chimeric

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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