Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Janelia Fluor 525

Antibody Source

Monoclonal Mouse IgG2B Clone # 705007

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Dynactin Subunit 1/DCTN1 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human Dynactin Subunit 1/DCTN1
Ala1145-Ser1278
Accession # Q14203

Specificity

Detects human Dynactin Subunit 1/DCTN1 in direct ELISAs, and huamn and mouse DCTN1 in Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human DCTN2 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Dynactin Subunit 1/DCTN1 Antibody (705007) [Janelia Fluor® 525]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Dynactin Subunit 1/DCTN1

The DCTN1 gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.

Alternate Names

DAP-150, DCTN1, DP-150, Dynactin 1, HMN7B

Gene Symbol

DCTN1

Additional Dynactin Subunit 1/DCTN1 Products

Product Documents for Dynactin Subunit 1/DCTN1 Antibody (705007) [Janelia Fluor® 525]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Dynactin Subunit 1/DCTN1 Antibody (705007) [Janelia Fluor® 525]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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