CXCR1/IL-8RA Antibody (42705R) [PE]
Novus Biologicals, part of Bio-Techne | Catalog # FAB330RP
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
CyTOF-reported, Flow Cytometry, Immunohistochemistry, Neutralization
Label
PE (Excitation = 488 nm, Emission = 575 nm)
Antibody Source
Recombinant Monoclonal Mouse IgG2A Clone # 42705R
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
NS0 mouse myeloma cell line transfected with human CXCR1/IL-8 RA
Met1-Leu350
Accession # AAA59159
Met1-Leu350
Accession # AAA59159
Specificity
Detects human CXCR1/IL-8 RA transfectants but not the parental cell line.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications for CXCR1/IL-8RA Antibody (42705R) [PE]
Application
Recommended Usage
CyTOF-reported
Optimal dilutions of this antibody should be experimentally determined.
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Neutralization
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from cell culture supernatant
Formulation
PBS
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: CXCR1/IL-8RA
CXCR1, also known as IL-8RA and CD181, is an approximately 60 kDa 7TM glycoprotein that functions as a receptor for the chemokine CXCL8/IL-8. It is expressed on neutrophils, monocytes, CD8 T cells, FoxP3+ CD4 Treg cells, mast cells, neuronal and glial cells, vascular endothelial cells, and melanoma. CXCR1 forms homodimers and heterodimers with CXCR2/IL-8RB. It can be cleaved from neutrophils in the lungs of cystic fibrosis patients to release fragments that promote CXCL8 production from airway epithelial cells. CXCR1 mediates neutrophil activation and chemotaxis to sites of inflammation as well as angiogenesis and melanoma invasiveness.
Long Name
Interleukin 8 Receptor A
Alternate Names
CD181, IL-8 RA, IL8RA
Additional CXCR1/IL-8RA Products
Product Documents for CXCR1/IL-8RA Antibody (42705R) [PE]
Product Specific Notices for CXCR1/IL-8RA Antibody (42705R) [PE]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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