CD27 Ligand/TNFSF7/CD70 Antibody [ADC] - (Vorsetuzumab Mafodotin, Research Grade)
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-44511
Key Product Details
Species Reactivity
Human
Applications
ELISA, Flow Cytometry, Functional
Label
ADC
Antibody Source
Monoclonal Human IgG1
Concentration
LYOPH mg/ml
Product Specifications
Immunogen
CD27 Ligand/TNFSF7 (Uniprot: P32970)
Clonality
Monoclonal
Host
Human
Isotype
IgG1
Theoretical MW
146.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Description
This product is an Antibody-Drug Conjugate (ADC) for Research Use Only (RUO).
Vorsetuzumab mafodotin is a humanized anti-CD70 monoclonal antibody attached to a potent, synthetic drug payload, monomethyl auristatin F (MMAF) utilizing Seattle Genetics' proprietary antibody-drug conjugate (ADC) technology. CD70 is expressed on a variety of solid tumors, including renal cell carcinoma, pancreatic, ovarian and lung cancer, as well as multiple myeloma and several types of non-Hodgkin lymphoma.
This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Vorsetuzumab mafodotin is a humanized anti-CD70 monoclonal antibody attached to a potent, synthetic drug payload, monomethyl auristatin F (MMAF) utilizing Seattle Genetics' proprietary antibody-drug conjugate (ADC) technology. CD70 is expressed on a variety of solid tumors, including renal cell carcinoma, pancreatic, ovarian and lung cancer, as well as multiple myeloma and several types of non-Hodgkin lymphoma.
This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Scientific Data Images
![Hu CD27 Ligand/TNFSF7 mAb [ADC] - (Vorsetuzumab Mafodotin)](https://resources.bio-techne.com/images/products/nbp3-44511_human-cd27-ligand-tnfsf7-vorsetuzumab-mafodotin-mab-elisa-182202610391116.png "ELISA: Hu CD27 Ligand/TNFSF7 mAb [ADC] - (Vorsetuzumab Mafodotin) [NBP3-44511]")
ELISA: Hu CD27 Ligand/TNFSF7 mAb [ADC] - (Vorsetuzumab Mafodotin) [NBP3-44511]
Immobilized humanCD70-His at 2 ug/mL (30 muL/well) can bind CD27 Ligand/TNFSF7 with the EC50 of 0.007612 ug/mL.
Flow Cytometry: CD27 Ligand/TNFSF7 (Vorsetuzumab Mafodotin) Antibody - Azide and BSA Free [NBP3-44511]
Human CD27 Ligand/TNFSF7 CHO-K1 Cell Line were stained with CD27 Ligand/TNFSF7 and negative control protein respectively, washed and then followed by PE and analyzed with FACS,The EC50 is 0.11mug/mL.Applications
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Functional
Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
> 90% by SDS-PAGE and HPLC
Reconstitution
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.
Formulation
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH mg/ml
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20C in powder form. Store at -80C once reconstituted.
Background: CD27 Ligand/TNFSF7
Alternate Names
CD70, TNFSF7
Additional CD27 Ligand/TNFSF7 Products
Product Specific Notices
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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