ATG16L1 Antibody (23GB665)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51235

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NBP3-51235-100ul
NBP3-51235-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB665

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ATG16L1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human ATG16L1 (Uniprot: Q676U5)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ATG16L1 Antibody (23GB665)

ATG16L1 Antibody (23GB665)

Immunocytochemistry/ Immunofluorescence: ATG16L1 Antibody (23GB665)[NBP3-51235] -

Immunocytochemical staining of HT-1080 cells with ATG16L1 antibody (1:1,000). Nuclei were stained blue with DAPI; ATG16L1 was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
ATG16L1 Antibody (23GB665)

Flow Cytometry: ATG16L1 Antibody (23GB665)[NBP3-51235] -

Flow cytometric analysis of ATG16L1expression in HT-1080 cells using ATG16L1 antibody (1:2,000). Green, isotype control; red, Atg16L1.

Applications for ATG16L1 Antibody (23GB665)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ATG16L1

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is essential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane. There are 5 isoforms of this protein (in human), with theoretical molecular weights ranging from ~19-68 kDa.

Mutations in the ATG16L1 proitein have been associated with Crohn's disease.

Alternate Names

APG16 autophagy 16-like (S. cerevisiae), APG16L beta, APG16LFLJ10828, APG16-like 1, ATG16 autophagy related 16-like (S. cerevisiae), ATG16 autophagy related 16-like 1 (S. cerevisiae), ATG16A, ATG16L, autophagy-related protein 16-1, FLJ00045, FLJ10035, FLJ22677, IBD10, WD repeat domain 30, WDR30

Gene Symbol

ATG16L1

Additional ATG16L1 Products

Product Documents for ATG16L1 Antibody (23GB665)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ATG16L1 Antibody (23GB665)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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