Caspase-4 Activity Assay Kit (Colorimetric)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-50231

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Key Product Details

Sample Type & Volume Required Per Well

Cell and tissue samples

View all Caspase-4 Activity Assays »

Product Specifications

Kit Type

Activity Assay Kit (Colorimetric)

Reactivity

Non-species specific

Description

Caspase 4, also known as Ich-2(ICE and CED-3 homolog 2), also known as TX and ICErel-II, can interact with Apaf-1 and participate in caspase 3 activation caused by cytochrome c. Caspase 4 can also interact with caspase 14. This caspase 4 activity assay kit is based on caspase 4 that can catalyze the substrate Ac-LEVD-pNA to generate yellow pNA (p-Nitroaniline). The pNA has a strong absorption near 405 nm, The activity of caspase 4 can be calculated by determining the absorbance at 405 nm.

Scientific Data Images for Caspase-4 Activity Assay Kit (Colorimetric)

Caspase-4 Activity Assay Kit (Colorimetric) Application: Caspase-4 Activity Assay Kit (Colorimetric) [NBP3-50231]

Application: Caspase-4 Activity Assay Kit (Colorimetric) [NBP3-50231]

Standard Curve of Caspase-4 Activity Assay Kit (Colorimetric) [NBP3-50231]

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C.

Background: Caspase-4

Caspase 4 encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Alternate Names

CASP4, Caspase4, ICE(rel)II, ICH-2, Mih1/TX, TX

Gene Symbol

CASP4

Additional Caspase-4 Products

Product Documents for Caspase-4 Activity Assay Kit (Colorimetric)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Caspase-4 Activity Assay Kit (Colorimetric)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Kits are guaranteed for 6 months from date of receipt.

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