YM 26734

Name: YM 26734
Brand: Tocris Bioscience
SKU: 2522

Catalog # 2522 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Secretory phospholipase A2 (sPLA2) inhibitor

Key Product Details

Description:	Secretory phospholipase A₂ (sPLA₂) inhibitor
Chemical Name:	1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone
Purity:	≥95% (HPLC)
Molecular Weight:	730.97

View Full Technical Details for YM 26734

Technical Data
Citations (2) / Reviews

Biological Activity for YM 26734

YM 26734 is a competitive inhibitor of secretory phospholipase A₂ (sPLA₂) that exhibits a broad inhibitory profile to several sPLA₂s (IC₅₀ values are 0.2, 1, 1, 1 and 3 μM for sPLA₂-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA₂-IIF and no activity at cytosolic PLA₂, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.

Technical Data for YM 26734

M. Wt	730.97
Formula	C₄₅H₆₂O₈
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	144337-18-8
PubChem ID	9853400
InChi Key	CEJAYJCUSZHYDS-UHFFFAOYSA-N
Smiles	OC1=C(C2CC(C4=CC=C(O)C=C4)OC3=C2C=CC(O)=C3)C(O)=C(C(CCCCCCCCCCC)=O)C(O)=C1C(CCCCCCCCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YM 26734

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	73.1	100
	ethanol	73.1	100

Preparing Stock Solutions for YM 26734

The following data is based on the product molecular weight 730.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.37 mL	6.84 mL	13.68 mL
5 mM	0.27 mL	1.37 mL	2.74 mL
10 mM	0.14 mL	0.68 mL	1.37 mL
50 mM	0.03 mL	0.14 mL	0.27 mL

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References for YM 26734

References are publications that support the biological activity of the product.

Hamaguchi Induction of distinct sets of secretory phospholipase A₂ in rodents during inflammation. Biochim.Biophys.Acta 2003 PMID: 14642775
Miyake Exogenous group II phospholipase A2 prostaglandin E2 production in mouse peritoneal macrophages. Eur.J.Pharmacol. 1994 PMID: 8013541
Miyake Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carregeenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A₂. Br.J.Pharmacol. 1993 PMID: 8220906

Citations for YM 26734 (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for YM 26734 include:

Pernet et al. (2014) Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun. 5:5105
PMID: 25290234
Bianca et al. (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Front Mol Neurosci. 161:1835
PMID: 20825409

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