VU 0155069

Name: VU 0155069
Brand: Tocris Bioscience
SKU: 3575
Price: 268 USD

Catalog # 3575 | Tocris Bioscience a Bio-Techne Brand

Citations (5)

COA / SDS

Potent and selective PLD1 inhibitor

Key Product Details

Description:	Potent and selective PLD1 inhibitor
Chemical Name:	N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	499.43

View Full Technical Details for VU 0155069

Biological Activity for VU 0155069

VU 0155069 is a potent and selective phospholipase D1 (PLD1) inhibitor (IC₅₀ values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.

Compound Libraries for VU 0155069

VU 0155069 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 0155069

M. Wt	499.43
Formula	C₂₆H₂₇ClN₄O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1781834-89-6
PubChem ID	56972237
InChi Key	RQULTQQAHGYYDG-LMOVPXPDSA-N
Smiles	O=C(N[C@@H](C)CN3CCC(N5C4=C(NC5=O)C=C(Cl)C=C4)CC3)C(C=C2)=CC1=C2C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0155069

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	49.94	100
	ethanol	24.97	50

Preparing Stock Solutions for VU 0155069

The following data is based on the product molecular weight 499.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	10.01 mL	20.02 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for VU 0155069

References are publications that support the biological activity of the product.

Scott Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat.Chem.Biol. 2009 PMID: 19136975
Lewis Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg.Med.Chem.Lett. 2009 PMID: 19268584

Citations for VU 0155069 (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for VU 0155069 include:

Eckart D et al. (2020) CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles. Cell Rep. 30:2444-2459.e7
PMID: 32075774
Krishnan et al. (2018) Elevated phopholipase D isoform 1 in Alzheimer's disease patient' hippocampus. Relevance to synaptic dysfunction and memory deficits. Alzheimers Dement (N Y). 4:89
PMID: 29560412
Lu et al. (2018) An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets. J Clin Med. 7
PMID: 30441821
Gang et al. (2017) PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage. Sci Rep. 7:6035
PMID: 28729535
Sulzmaier et al. (2012) PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene. 31:3547
PMID: 22105357

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