Src I1

Tocris Bioscience, part of Bio-Techne | Catalog # 3642

Dual site Src kinase inhibitor
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Key Product Details

Description

Dual site Src kinase inhibitor

View all Src Family Kinase Inhibitors »

Product Description

Src I1 is a potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.

Product Specifications

Molecular Weight

373.40

Formula

C22H19N3O3

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine

CAS Number

179248-59-0

PubChem ID

1474853

InChI Key

DMWVGXGXHPOEPT-UHFFFAOYSA-N

SMILES

COC(C(OC)=C3)=CC1=C3N=CN=C1NC2=CC=C(OC4=CC=CC=C4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.34 100

Preparing Stock Solutions for Src I1

The following data is based on the product molecular weight 373.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Src I1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Src I1

For research use only

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