R 715

Catalog # 3407 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (6)

COA / SDS

Potent and selective B1 antagonist

Key Product Details

Description:	Potent and selective B₁ antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1140.35

View Full Technical Details for R 715

Technical Data
Citations (6) / Reviews (1)

Biological Activity for R 715

R 715 is a potent and selective bradykinin B₁ receptor antagonist (pA₂ = 8.49). Displays no activity at B₂ receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.

Technical Data for R 715

M. Wt	1140.35
Formula	C₅₇H₈₁N₁₃O₁₂
Single Letter Sequence	KRPPGFSXI (Modifications: Lys-1 = N-terminal Ac, X = DβNal)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	185052-09-9
PubChem ID	5311397
InChi Key	DOSXOGUJJBDRGQ-VUBDHFCFSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for R 715

Solubility

Soluble to 5mg/ml in water

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References for R 715

References are publications that support the biological activity of the product.

Quintao Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B₁ and B₂ receptors. J.Neurosci. 2008 PMID: 18337416
Abdouh Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B₁ and B₂ receptors. Br.J.Pharmacol. 2008 PMID: 18311190
Gobeil Structure-activity studies of B₁ receptor-related peptides. Hypertension. 1996 PMID: 8901831

Citations for R 715 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for R 715 include:

Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience. 365:23
PMID: 28951324
Falsetta et al. (2016) A role for bradykinin signaling in chronic vulvar pain. The Journal of Pain. 2016;
PMID: 27544818
Kawaguchi et al. (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. J Cereb Blood Flow Metab. 9:229
PMID: 26124706
Xu et al. (2014) Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Am J Respir Cell Mol Biol. 51:370
PMID: 24669857
Pinheiro et al. (2013) Bradykinin-induced Ca²⁺ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal. 11:70
PMID: 24047499
Albert-Weissenberger et al. (2012) Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. EMBO Mol Med. 32:1747
PMID: 22569191

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Customer Reviews for R 715 (1)

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works good

Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: neurons

B1 receptor antagonist R715, 2 µM

treat 20 min

PMID: 28951324 Reference

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