Myelin Basic Protein (87-99)

Name: Myelin Basic Protein (87-99)
Brand: Tocris Bioscience
SKU: 3399

Catalog # 3399 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Major antigenic component implicated in the pathophysiology of multiple sclerosis

Key Product Details

Description:	Major antigenic component implicated in the pathophysiology of multiple sclerosis
Purity:	≥95% (HPLC)
Molecular Weight:	1555.8

View Full Technical Details for Myelin Basic Protein (87-99)

Technical Data
Citations / Reviews

Biological Activity for Myelin Basic Protein (87-99)

Myelin Basic Protein (87-99) is an encephalitogenic peptide that induces T cell proliferation with Th1 polarization in the CNS. Major antigenic component implicated in the pathophysiology of multiple sclerosis.

Technical Data for Myelin Basic Protein (87-99)

M. Wt	1555.8
Formula	C₇₄H₁₁₄N₂₀O₁₇
Single Letter Sequence	VHFFKNIVTPRTP
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	118506-26-6
PubChem ID	25077562
InChi Key	XSSZRUKIAIQNAZ-SAKFXWCOSA-N
Smiles	[H]N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Myelin Basic Protein (87-99)

Solubility

Soluble to 2mg/ml in water

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References for Myelin Basic Protein (87-99)

References are publications that support the biological activity of the product.

Deraos Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP87-99) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: Implications in triggering disease. J.Med.Chem. 2008 PMID: 19053745
Hofstetter Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis? J.Immunol.
Jones The synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats. J.Neuroimmunol. 1992 PMID: 1373154

Citations for Myelin Basic Protein (87-99)

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