Gambogic acid

Name: Gambogic acid
Brand: Tocris Bioscience
SKU: 3590

Tocris Bioscience, part of Bio-Techne | Catalog # 3590

Citations (23)

COA / SDS

Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins

Discontinued Product

3590 has been discontinued. View all Apoptosis Inducer Compounds products.

Key Product Details

Description:	Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins
Chemical Name:	(2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid
Molecular Weight:	628.75

View Full Technical Details for Gambogic acid

Technical Data
Citations

Biological Activity for Gambogic acid

Gambogic acid is an apoptosis inducer in several tumor cell lines including T47D cells. Activates caspases (EC₅₀ values are 0.78 - 1.64 μM) and competitively inhibits antiapoptotic Bcl-2 family proteins (IC₅₀ values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Reverses gefitinib-resistance in mice bearing tumors with EGFR-T790M mutation. Also blocks K_ir2.1 channels (EC₅₀ ≤ 100 nM).

Technical Data for Gambogic acid

M. Wt	628.75
Formula	C₃₈H₄₄O₈
Storage	Store at -20°C
CAS Number	2752-65-0
PubChem ID	15559465
InChi Key	GEZHEQNLKAOMCA-MYCCNKBCSA-N
Smiles	C/C(C)=C/CC[C@@](C=C2)(C)OC1=C2C(O)=C(C(C([C@]45O3)=C[C@H](C[C@@H]56)C([C@](OC(C)6C)4C/C=C(C(O)=O)/C)=O)=O)C3=C1C/C=C(C)/C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Gambogic acid

References are publications that support the biological activity of the product.

Wang Combined therapy with EGFR TKI and gambogic acid for overcoming resistance in EGFR-T790M mutant lung cancer. Oncol.Lett. 2015 PMID: 26622796
Zaks-Makhina Specific and slow inhibition of the Kir2.1 K⁺ channel by Gambogic acid. J.Biol.Chem. 2009 PMID: 19366693
Zhai Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins. Mol.Cancer Ther. 2008 PMID: 18566235
Qi Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells. Biochem.Cell Biol. 2008 PMID: 18923540
Zhang Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. Bioorg.Med.Chem. 2004 PMID: 14723951

Gambogic acid

Tocris Bioscience, part of Bio-Techne | Catalog # 3590

Key Product Details

Biological Activity for Gambogic acid

Technical Data for Gambogic acid

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Gambogic acid

Product Documents for Gambogic acid

COA

Certificate of Analysis

SDS

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